Endocrine Abstracts

Cushing’s syndrome is associated with life-threatening complications, as well as high rates of perioperative mortality and morbidity. Authors present clinical scenarios, in which one should consider the usage of intravenous etomidate as an accurate, safe and effective drug for hypercortisolaemia.Case 1: 23-year-old female with severe Cushing’s syndrome due to metastatic adrenocortical carcinoma was admitted to the Department of Endocrinology. S...

Introduction: Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, combined together, under the name of MELAS syndrome, constitute one of the mitochondrial genetic diseases with dominant progressive neurodegenerative symptoms. Although nervous system involvement is often the first manifestation of the disease, during the course of the disorder, patient can develop a wide spectrum of endocrine disorders ranging from GH deficiency and hypoparathyroi...

Introduction: Acromegaly with normal IGF-1level is rarely diagnosed and is difficult to recognize. In acromegalic pa-tients with poorly controlled diabetes, malnutrition, hepatic injury, hepatic congestion due to heart fail-ure, inflammatory diseases, renal dysfunction, and malignant neoplasm, IGF-1 synthesis is inhibited and thus in such cases normal IGF-1 levels may be observed. The aim of the study is to present a rare case of a patient with acromegaly and normal IGF-1 leve...

Introduction: Chemodectomas of carotid glomus secret mainly catecholamines and/or ACTH. These tumours are very rare cause of ectopic secretion of parathormone (PTH), althought this possibility should be taken into consideration. Therefore, diagnosis of primary hyperparathyroidism (PHPT) as a cause of hypercalcemia in patients with chemodectoma tumours is problematic and may lead to inappropriate diagnosis and treatment. Presented patient is a 64-years old female with non-opera...

HAIR-AN is a rarely recognized syndrome which is characterized by hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). In the course of the syndrome, anovulation and metabolic disorders can develop, too. It is therefore suggested by some authors that HAIR-AN is an extreme phenotype of the polycystic ovary syndrome (PCOS). Generally, considering wide spectrum of metabolic and endocrine disorders which can be associated with the syndrome, it still remain...

IntroductionTreatment of choice in acromegaly is transsphenoidal resection of GH-secreting pituitary adenoma. Its efficacy ranges from 28% to 83% depending on tumor size and location. Random GH < 1 µg/l or nadir GH in OGTT < 0.4 µg/l and normal IGF-1 are found to be the evidence of effective surgery. However, some patients diagnosed with acromegaly remission after surgery present discordant GH and IGF-1 results.Ai...

95% of all cases of overt hypothyroidism are primary. It is defined as low levels of blood thyroid hormone due to disorder of the thyroid gland causing decreased synthesis and secretion of thyroid hormones. Levothyroxine is recommended as the preparation of choice for the treatment of this disease. The therapy should eliminate the symptoms of hypothyreosis, lead to the normalization of thyroid axis hormones and the avoidance of iatrogenic thyrotoxicosis. Serum TSH is the param...

Objective: Hypothyroidism is one of the most common disturbances of thyroid function caused by a thyroid hormone deficiency, found predominantly in young women. The general slowdown of metabolic processes and low-grade chronic inflammatory state occurs in the broad spectra of clinical hypothyroidism manifestations. Although several risk factors of hypothyroidism have been identified, the exact pathogenic mechanisms remain unexplained. The conventional treatment of hypothyroidi...

Introduction: Adipocyte fatty acid binding protein (A-FABP) is mainly expressed in adipocytes, and circulating A-FABP has been associated with markers of obesity. Women with PCOS are at increased risk of developing abdominal obesity what could be related to serum concentration of A-FABP.Aim: The aim of the present study was to investigate the relationships between serum concentration of A-FABP and parameters of obesity e.g. waist to hip ratio (WHR) and t...

Introduction: Polycystic ovary syndrome (PCOS) is associated with an increased risk of abdominal obesity, what is regulated by numerous genetic, epigenetic, and environmental factors. MicroRNAs (miRNAs) are known regulators of gene expression, involved in the development of metabolic disturbances. Dual-energy X-ray absorptiometry (DXA) is an accurate method of body composition analysis. The aim of the present study was to investigate the association between circulating miRNAs,...